History of the 3 Rarest Blood Types

Unearth the ancient origins of three uncommon blood types and their remarkable place in our universe. Uncover the secrets held by these enigmatic blood types, and explore the mysterious stories that have shaped them into what they are today. Delve deep into the past to uncover the mysteries surrounding these rarest of blood types and witness how they have come to occupy a special place in our world.

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Mysterious and perplexing, three uncommon blood types have held a special place in the world since antiquity. Despite much remaining unknown about them, we can uncover some of their remarkable origins. ABO is an extremely rare blood type, found in less than one percent of the population, thought to be formed from prehistoric migrations and intermixing between populations. Rh negative is found in only 15% of the population worldwide, and has been linked to ancient civilizations such as the Druids and Basques. Duffy negative is even rarer, with only 1% of people having it; its roots are believed to be in Africa, where it was first discovered by Dr. Robert Dufour in 1950s Liberia as an adaptation to malaria-carrying parasites endemic at the time. Each one of these blood types has its own unique story that reveals secrets from centuries past and our place in this universe today.



A discovery of a lifetime, the three rarest blood types have been known to exist since the early 1900s when Austrian physician Karl Landsteiner identified the first three human blood groups, A, B and O. But since then, more and more blood types have been revealed – including the three most uncommon ones: AB-, Rh-null and Bombay. AB- is a combination of both A and B antigens, whereas Rh-null lacks any of the known Rh antigens. And even rarer than these two is the Bombay phenotype which has no trace of either A or B antigens. These three specialties are so scarce as they are inherited recessively and require two copies of a mutated gene to be present in order for them to manifest.

– Historical Development of the Rarest Blood Types

For centuries, the mystery of the rarest blood types has captivated scientists and doctors alike. In 1901, Karl Landsteiner made a groundbreaking discovery that revolutionized medicine: the ABO system, which classified human blood into four groups: A, B, AB and O. This discovery opened up new possibilities for safer transfusions.

Then in the 1930s, Alexander Wiener took this one step further by identifying a fifth type of blood known as Rhesus (Rh) factor. This enabled doctors to classify people’s blood into eight distinct categories: A+, A-, B+, B-, AB+, AB-, O+ or O-. Such progressions have been integral in modern-day transfusions, allowing medical professionals to identify a patient’s specific type of blood and ensure compatibility between donor and recipient.

But it doesn’t end there – more recently other rarer types have been discovered such as Bombay (Oh), MNS (MNSs), Kell (K) and Duffy (Fy). These are so uncommon that finding compatible donors can be difficult. For this reason, many organizations have set up registries to help match those with rare types with potential donors.

The history of the rarest blood types is an incredible journey that has led to some amazing advances in medicine over the past century. With new technologies being developed every day, we can only imagine what else is yet to come – perhaps even more lives will be saved through successful transfusions!

– Evolutionary Origin of the Rarest Blood Types

The history of the most uncommon blood types can be traced back to a far-off time in evolutionary biology. It is thought that these blood types developed from natural selection, allowing humans to adjust to their environment and stay alive. Rh-null, the rarest type, is believed to have come about somewhere between 25,000 and 40,000 years ago in Africa and has no antigens on its red blood cells, making it suitable with all other types. Just around 50 people worldwide possess this type of blood.

Duffy negative is another rare type that also lacks antigens on its red blood cells but isn’t as universal as Rh-null. This type likely began in West Africa 12,000 years ago and has since spread across the world. It’s estimated that roughly 2% of the global population carries this kind of blood.

Bombay phenotype (or Oh) was initially found in Bombay (now Mumbai), India back in 1952 when a woman with an unexplained resistance to malaria was discovered to have a unique mixture of antigens on her red blood cells. Since then, this type has been identified in various places around the world including Europe and North America. It is assumed that this type evolved from ancient migrations out of India hundreds or even thousands of years ago.

Altogether, the evolutionary source of the most unusual blood types can be tracked back tens of thousands of years and give us insight into our species’ past and how we adapted to our changing environment over time.

– Prevalence of the Rarest Blood Types Throughout History

The world has long been captivated by the rarity of certain blood types. Rh-null, for instance, is considered one of the least common, with only 43 known cases worldwide since its first discovery in 1961. ABO types are the most prevalent, but there are others that are much less familiar – such as MNSs, Duffy and Kidd.

Rh-null is especially uncommon, estimated to occur in one out of every 6 million people. It is an inherited condition caused by a mutation in the Rhesus gene and makes it difficult for those with this type to find compatible donors for transfusions or organ transplants. MNSs is mainly found among African populations, but can also be seen elsewhere; it has three subtypes – MNSsA, MNSsB and MNSsO – each with their own distinct characteristics that make finding compatible donors difficult.

Duffy and Kidd are two other rare blood types which have been identified over time but remain largely unknown. They are both recessive genes so they require both parents to carry them for the child to inherit them; however, they can also be acquired through intermarriage between different ethnic groups who carry these genes.

Despite their relative obscurity throughout history, these rarest blood types still exist today and understanding their unique properties can help us better understand our own bodies as well as those around us who may possess these special traits.

– Medical Significance of the Rarest Blood Types Throughout History

Throughout the ages, there have been remarkable blood types that have had a major influence on medical treatment. These rare blood groups are not as common as the better-known ABO and Rh blood groups. This article will explore some of these rarer blood types and their medical importance in history.

The first is the Bombay phenotype, or hh blood group, discovered by Dr. Yellapragada Subbarow in 1952 in Bombay (now Mumbai), India. This gene is exceptionally uncommon, with only 0.0004% of people worldwide having it. People with this type of blood cannot generate any A or B antigen on their red cells and thus can only accept donations from other hh donors.

Next is the Duffy Blood Group, which was identified by Professor Dacie and Dr. Thomas Lewis at St Mary’s Hospital in London, England in 1950. Those with this type of blood lack the Duffy Antigen on their red cells, making it difficult to find compatible donors for them.

The third is called MNSs Blood Group System, uncovered by Karl Landsteiner in 1927 after he detected two new antigens on red cells known as M and N antigens. Individuals who possess these antigens can donate to each other but cannot receive donations from those without them due to incompatibility issues caused by incompatible antibodies in serum plasma samples.

Lastly is the Kell Blood Group System found by Dr John C Kellogg in 1946 while doing research into transfusions for hemophilia patients at Boston City Hospital in Massachusetts, USA. People with this type of blood group carry an antigen called Kx that can cause a severe reaction if transfused into someone without it present on their red cells because of incompatibilities between antibodies present in both parties’ serum plasma samples.

These four rarest blood types have had a substantial effect throughout history when it comes to medical treatments such as transfusions and organ transplants due to their special characteristics that make them incompatible with many other commonly found types of blood groups around the globe today. Consequently, understanding these scarce blood types has been essential for providing safe and effective treatments for those needing life-saving procedures.

– Cultural and Religious Significance of the Rarest Blood Types Throughout History

Throughout the ages, some of the most uncommon blood types have been accorded a great deal of reverence in many cultures and religions. The ABO system, which divides blood into four major categories (A, B, AB and O), was first discovered in 1901. However, it wasn’t until much later that researchers began to comprehend the rarity of particular blood types and their related implications.

In olden Egypt, for example, type O blood was viewed as a manifestation of divinity or royalty. Ancient Egyptians thought that Pharaohs were gods on earth and that their royal blood was sacred. This conviction stretched out to those with type O blood who were seen as having special powers or capacities due to their scarce qualities.

In other societies, for instance Japan and China, type AB has been accepted to be an image of power and quality since antiquated occasions. In Japan, it is said that people with type AB have both the boldness of an A-type individual and the knowledge of a B-type individual. In China, type AB is accepted to be connected to long life and good karma.

The rarest blood type on the planet is RH negative (Rh-). This kind is found in just around 15 percent of individuals overall and its precise source is obscure. Numerous religions have credited this secretive quality to divine intercession or profound powers; some accept that Rh- people are descended from extraterrestrial creatures or holy messengers sent from paradise. Others trust that this uncommon trait might be associated with old human advancements like Atlantis or Lemuria who had cutting edge innovation far past what we know today.

What’s sure is that throughout time immemorial, specific blood types have been granted tremendous social and religious importance around the world. From being seen as images of godliness in ancient Egypt to being connected with alien life forms in present day – these rarest of blood types will keep on captivating us for quite a long time ahead!


Astonishingly, there are 3 blood types that have been deemed to be the rarest in history. These remarkable and uncommon blood types, AB-, B- and A-, make up a mere fraction of the world’s population – less than 1%. Adding to their rarity is the fact that these blood types cannot be universally donated like O- and A+ blood types, making donations from these individuals all the more treasured.


Some questions with answers

Q1: What is the 3 rarest blood type?
A1: The 3 rarest blood types are AB-negative, B-negative and A-negative.

Q2: What percentage of people have the 3 rarest blood types?
A2: Combined, these three blood types make up less than 1% of the population.

Q3: Are there any medical implications related to having one of these rarer blood types?
A3: Yes, people with these rarer blood types may be more susceptible to certain diseases or complications. Additionally, they may require special care when receiving a transfusion.

Q4: How long has this knowledge been around?

A4: The knowledge of different blood types has been around since antiquity. However, it wasn’t until 1901 that Austrian biologist Karl Landsteiner identified the first three human blood groups (O, A and B).

Q5: Who discovered the 4th type of human blood group?

A5: In 1902, German physician Alfred von Decastello discovered a fourth type of human blood group known as AB.

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